2. Signaling Pathways
  3. GPCR/G Protein
  4. Angiotensin Receptor

Angiotensin Receptor

Angiotensin Receptor

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Angiotensin receptors are a class of G protein-coupled receptors with angiotensin II as their ligands. They are important in the renin-angiotensin system: they are responsible for the signal transduction of the vasoconstricting stimulus of the main effector hormone, angiotensin II. The AT1 and AT2 receptors have a similar affinity for angiotensin II, which is their main ligand. The AT1 receptor is the best elucidated angiotensin receptor. AT2 receptors are more plentiful in the fetus and neonate. Other poorly characterized subtypes include the AT3 and AT4 receptors.

Angiotensin Receptor Isoform Specific Products:

Angiotensin Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P2381
    Sar-Arg-Val-Tyr-Val-His-NH2
    		Agonist
    Sar-Arg-Val-Tyr-Val-His-NH2 is a Gq-biased agonists, exhibits 10-fold larger molecular efficacies at the AT1R-Gq fusion protein compared with the AT1R-βarr2 fusion protein.
    Sar-Arg-Val-Tyr-Val-His-NH2
  • HY-P1415A
    Norleual TFA
    		Antagonist 99.93%
    Norleual TFA, an angiotensin (Ang) IV analog, is a hepatocyte growth factor (HGF)/c-Met inhibitor with an IC50 of 3 pM. Norleual TFA is an AT4 receptor antagonist and exhibits potent antiangiogenic activities.
    Norleual TFA
  • HY-15477A
    YS-49 monohydrate
    		Inhibitor 99.56%
    YS-49 (monohydrate) is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells. YS-49 inhibits angiotensin II (Ang II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1. YS-49 is also an isoquinoline compound alkaloid, has a strong positive inotropic action through activation of cardiac β-adrenoceptors.
    YS-49 monohydrate
  • HY-13955S
    Telmisartan-d3
    		Antagonist 99.77%
    Telmisartan-d3 is the deuterium labeled Telmisartan. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM.
    Telmisartan-d<sub>3</sub>
  • HY-P1519B
    Brain Natriuretic Peptide (1-32), rat acetate
    		98.66%
    Brain Natriuretic Peptide (1-32), rat acetate (BNP (1-32), rat acetate) is a 32 amino acid polypeptide secreted by the ventricles of the heart in response to excessive stretching of heart muscle cells (cardiomyocytes).
    Brain Natriuretic Peptide (1-32), rat acetate
  • HY-B0202S
    Irbesartan-d4
    		Antagonist 99.46%
    Irbesartan-d4 is the deuterium labeled Irbesartan, which is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist.
    Irbesartan-d<sub>4</sub>
  • HY-19732
    BIBS 39
    		Antagonist 99.70%
    BIBS 39 is a new nonpeptide angiotensin II (AII) receptor antagonist.
    BIBS 39
  • HY-12765S
    Losartan-d4 (carboxylic acid)
    		Antagonist 98.17%
    Losartan-d4 (carboxylic acid) is the deuterium labeled Losartan (EXP-3174), which is an angiotensin II receptor antagonist.
    Losartan-d<sub>4</sub> (carboxylic acid)
  • HY-102093
    ZD 7155(hydrochloride)
    		Antagonist 99.88%
    ZD 7155 hydrochloride is an angiotensin II receptor type 1 (AT1 receptor) antagonist.
    ZD 7155(hydrochloride)
  • HY-120979
    NO-Losartan A
    		Activator 98.33%
    NO-Losartan A (compound 2a) displays vasorelaxing effects, due to the release of NO, and antagonized the vasocontractile effects of Angiotensin II (HY-13948), with potency values similar to that of Losartan (HY-17512).
    NO-Losartan A
  • HY-18706
    trans-Tranilast
    		Inhibitor 98.99%
    trans-Tranilast (trans-MK-341) is an antiallergic drug, used to treat bronchial asthma, allergic rhinitis and atopic dermatitis.
    trans-Tranilast
  • HY-P0205
    Saralasin
    		Antagonist 98.71%
    Saralasin ([Sar1,Ala8] Angiotensin II) is an octapeptide analog of angiotensin II. Saralasin is a competitive angiotensin II receptor antagonist with a Ki value of 0.32 nM for 74% of the binding sites, and has partial agonist activity as well. Saralasin can be used for the research of renovascular hypertension, renin-dependent (angiotensinogenic) hypertension.
    Saralasin
  • HY-B0205S
    Candesartan-d4
    		Antagonist 98.85%
    Candesartan-d4 is the deuterium labeled Candesartan, which is an angiotensin II receptor antagonist.
    Candesartan-d<sub>4</sub>
  • HY-112824
    L-162313
    		Agonist 98.51%
    L-162313 is a non-peptide angiotensin II AT1 and AT2 receptor agonist, with IC50 values of 1.1 and 2.0 nM for AT1 and AT2 receptor, respectively. L-162313 can be used for the research of vasoconstriction, aldosterone release, and cardiovascular growth.
    L-162313
  • HY-P3910
    [Val4] Angiotensin III
    		Activator 98.51%
    [Val4] Angiotensin III is an angiotension III peptide. [Val4] Angiotensin III is a potent full agonist of Gαq and βarr2 response, with pEC50 values of 8.31 and 8.44, respectively.
    [Val4] Angiotensin III
  • HY-P3138
    (Sar1)-Angiotensin II
    		Agonist 99.84%
    (Sar1)-Angiotensin II, an analogue of Angiotensin II, is a specific agonist of angiotensin AT1 receptor. (Sar1)-Angiotensin II binds to brain membrane-rich particles, with a Kd of 2.7 nM. (Sar1)-Angiotensin II can stimulate protein synthesis and cell growth in embryonic chick myocytes.
    (Sar1)-Angiotensin II
  • HY-P0080
    Novokinin
    		Agonist
    Novokinin is a peptide agonist of the angiotensin AT2 receptor.
    Novokinin
  • HY-17512S
    Losartan-d4
    		Chemical 99.93%
    Losartan-d4 is the deuterium labeled Losartan. Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.
    Losartan-d<sub>4</sub>
  • HY-B0205S1
    Candesartan-d5
    		Antagonist
    Candesartan-d5 is the deuterium labeled Candesartan. Candesartan is an angiotensin II receptor antagonist with IC50 of 0.26 nM.
    Candesartan-d<sub>5</sub>
  • HY-P1515A
    Angiotensin II (3-8), human TFA
    		Agonist 99.90%
    Angiotensin II (3-8), human (TFA) is a less effective agonist at the angiotensin AT1 receptor.
    Angiotensin II (3-8), human TFA
Cat. No. Product Name / Synonyms Application Reactivity
Angiotensin Receptor Isoform Comparison

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